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CHEM 7210 STRUCTURE ELUCIDATION OF ORGANIC COMPOUNDS (3) LEC. The early stages of this course will focus on the identification of functional groups, saturated, unsaturated and cyclic compounds using IR and NMR spectroscopy, as well as mass spectrometry. Detailed analyses of 1H NMR spectra, i.e., chemical shift, multiplet shape, and coupling constants will demonstrate the power of these methods in ascertaining atom connectivity in simple organic molecules. More advanced two-dimensional NMR techniques such as COSY, HSQC and HMBC will be discussed and used for determining the structures of more complex organic molecules.
The determination of absolute and relative stereochemistry using Mosher ester analyses and NOESY, respectively, in chiral molecules will also be covered. Most of the structures that will be discussed and analyzed will be stereochemically complex systems and polycyclic molecules that require a combination of multiple one-dimensional and two-dimensional NMR techniques.
CHEM 7230 COMPLEX MOLECULE SYNTHESIS (3) LEC. This class is focused on target-oriented chemical synthesis of complex organic molecules. The main objective is to teach students how to use retrosynthetic analysis, a method for disconnecting a complex molecule into simpler starting materials, as well classical and modern organic reactions to plan syntheses of organic compounds that are biologically relevant and important in the development of better pharmaceuticals. During the course of the semester, students will be introduced to important classes of natural products including terpenes, terpenoids, alkaloids, macrolides, polycyclic ethers, as well as designed molecules that are biologically relevant, but not natural products themselves.
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Identifying key structural components (i.e., retrons), stereogenic centers, and substructures that can be derived from the chiral pool will be emphasized in synthesis planning. All lecture content will come from the current literature, with only manuscripts published in the past 12 months being discussed in class. Business plan pro 11 keygen download for hex key.
Students will be responsible for reading Classics in Total Synthesis on their own and tested on the content of this book as well as assigned current literature in class. Emphasis will be placed on identifying economical and streamlined synthetic protocols that can employ cascade or domino reaction sequences.
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CHEM 7410 A DBER APPROACH TO TEACHING AND LEARNING IN CHEMISTRY (3) LEC. Discipline-based education research (DBER) theory andtrends, consuming and evaluating DBER research, activelearning in advanced chemistry topics, action research,review of pedagogical tools, assessment. This coursewill be of use to chemistry graduate students aimingfor careers in academia, masters education studentslooking to take a chemistry course for the fulfillmentof their degree requirements, and other fields that wantto know more about evaluating and critiquing current DBERliterature and methods.